Knowledge Base

Pet Nutrition & Longevity Research

Evidence-based insights on nutrition, supplementation, training, and recovery — written by an owner who applies this work daily with his own animals.

Hormone Replacement Therapy for Senior Dogs
Supplementation

Hormone Replacement Therapy for Senior Dogs

Is traditional spay/neuter always the best choice for your dog's long-term health? New research reveals a hidden hormonal crisis, linking sterilization to a higher risk of cancer, joint disease, and accelerated aging. Discover how emerging hormone replacement therapies and hormone-sparing sterilization techniques are creating a new frontier in canine longevity science.

Hormone Replacement TherapyHRTDog Longevity
10 min readMar 12, 2026
Creatine Supplementation in Aging Dogs: A Narrative Review of Bioavailability, Efficacy, Safety, and Longevity Applications
Supplementation

Creatine Supplementation in Aging Dogs: A Narrative Review of Bioavailability, Efficacy, Safety, and Longevity Applications

Most dogs fed commercial diets are functionally creatine-deficient due to the near-complete destruction of dietary creatine during high-heat pet food manufacturing — a critical and underappreciated nutritional gap with real consequences for muscle, brain, and heart health as dogs age. Emerging research demonstrates that creatine supplementation in dogs improves high-intensity athletic performance, combats age-related muscle loss (sarcopenia), protects against cognitive decline, and supports cardiac bioenergetics, making it one of the most compelling multi-target longevity interventions available to proactive pet owners today. This review synthesizes the current evidence, identifies guanidinoacetic acid (GAA) as the most stable and bioavailable delivery form for creatine in commercial diets, and provides practical, veterinarian-informed dosing guidance for senior, athletic, and at-risk dogs.

creatine; guanidinoacetic acid; canine aging; sarcopenia; Canine Cognitive Dysfunction; phosphocreatine; longevity; healthspan; pet nutrition; cardiac bioenergetics; neuroprotection; creatine kinase; GAA; senior dog; veterinary supplementation
16 min readMar 5, 2026